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Dr. Sarah Burney, Dr. Ringo Wenzel, Priv.-Doz. Dr. Tilman Kottke, Thomas Roussel, Dr. Nathalie Hoang, Dr. Jean-Pierre Bouly, Prof. Dr. Robert Bittl, Prof. Dr. Joachim Heberle and Prof. Dr. Margaret Ahmad Single Amino Acid Substitution Reveals Latent Photolyase Activity in Arabidopsis cry1 Angewandte Chemie International Edition 51

Article first published online: 13 AUG 2012 | DOI: 10.1002/anie.201203476

Thumbnail image of graphical abstract

A quick switch: A single amino acid substitution at a conserved residue (D396N) of Arabidopsis cryptochrome-1 (Atcry1) confers single-stranded DNA repair activity in vitro, conferring photolyase activity onto the cryptochrome (see graph). The mutant protein undergoes photoreduction of flavin to the fully reduced anionic form, similar to photolyases and unlike wild-type cryptochromes.

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