Dr. Sarah Burney, Dr. Ringo Wenzel, Priv.-Doz. Dr. Tilman Kottke, Thomas Roussel, Dr. Nathalie Hoang, Dr. Jean-Pierre Bouly, Prof. Dr. Robert Bittl, Prof. Dr. Joachim Heberle and Prof. Dr. Margaret Ahmad Single Amino Acid Substitution Reveals Latent Photolyase Activity in Arabidopsis cry1 Angewandte Chemie International Edition 51
A quick switch: A single amino acid substitution at a conserved residue (D396N) of Arabidopsis cryptochrome-1 (Atcry1) confers single-stranded DNA repair activity in vitro, conferring photolyase activity onto the cryptochrome (see graph). The mutant protein undergoes photoreduction of flavin to the fully reduced anionic form, similar to photolyases and unlike wild-type cryptochromes.
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