Dr. Christian Gil Girol, Dr. Katja M. Fisch, Dr. Thorsten Heinekamp, Jun.-Prof. Dr. Stefan Günther, Dr. Wolfgang Hüttel, Prof. Dr. Jörn Piel, Prof. Dr. Axel A. Brakhage and Prof. Dr. Michael Müller Regio- and Stereoselective Oxidative Phenol Coupling in Aspergillus niger Angewandte Chemie International Edition 51
Piecing it together: Aspergillus niger produces kotanin (see structure) by dimerization of the monomeric, polyketide-synthase-derived (PKS) 7-demethylsiderin. A combined approach, comprising bioinformatics and gene-deletion experiments, identified the biosynthetic cluster responsible for kotanin production. Homology modeling and substrate docking provide a rationale for the regio- and stereoselective phenol coupling reaction.
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