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Dr. Xinfang Xu, Dr. Peter Y. Zavalij and Prof. Michael P. Doyle Synthesis of Tetrahydropyridazines by a Metal–Carbene-Directed Enantioselective Vinylogous N[BOND]H Insertion/Lewis Acid-Catalyzed Diastereoselective Mannich Addition Angewandte Chemie International Edition 51

Version of Record online: 3 SEP 2012 | DOI: 10.1002/anie.201203962

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A versatile cascade of reactions, triggered by RhII-catalyzed diazo decomposition followed by a vinylogous N[BOND]H insertion/Lewis acid catalyzed Mannich addition, that produces highly substituted 1,2,3,6-tetrahydropyridazines in up to 97 % ee with high yield and diastereocontrol has been developed.

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