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Dr. Zeyu Xiao, Dr. Changwei Ji, Dr. Jinjun Shi, Eric M. Pridgen, Jillian Frieder, Dr. Jun Wu and Prof. Omid C. Farokhzad DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy Angewandte Chemie International Edition 51

Version of Record online: 18 OCT 2012 | DOI: 10.1002/anie.201204018

Thumbnail image of graphical abstract

Targeted cancer therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (see picture; PEG=polyethylene glycol). This DNA-based platform shows the ability of releasing therapeutics upon near-infrared irradiation, and remarkable targeted thermo- and chemotherapeutic efficacy in vitro and in vivo.

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