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Hao-Wei Shih, Yi-Fan Chang, Wei-Jing Li, Fan-Chun Meng, Chia-Ying Huang, Dr. Che Ma, Dr. Ting-Jen R. Cheng, Prof. Dr. Chi-Huey Wong and Dr. Wei-Chieh Cheng Effect of the Peptide Moiety of Lipid II on Bacterial Transglycosylase Angewandte Chemie International Edition 51

Article first published online: 5 SEP 2012 | DOI: 10.1002/anie.201204038

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The writing's on the (cell) wall: A series of Lipid II analogues with modifications to the peptide moiety were evaluated as substrates of bacterial transglycosylase. The first two positions on the peptide, D-lactate and L-alanine (see scheme), especially their methyl groups, were found to be essential for substrate-binding activity, an important discovery for the design of antibiotics to inhibit cell-wall biosynthesis.

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