Dr. Diego A. Fort, Dr. Thomas J. Woltering, Dr. Matthias Nettekoven, Dr. Henner Knust and Prof. Dr. Thorsten Bach Synthesis of Fluorinated Tricyclic Scaffolds by Intramolecular [2+2] Photocycloaddition Reactions Angewandte Chemie International Edition 51
Fabulous Fluorine: The synthesis of fluorinated products 1 and 2 by [2+2] photocycloaddition was readily feasible after optimization of the irradiation conditions. The electron-deficient trifluoroolefin unit reacted intramolecularly to products 1 (nine examples, d.r.>95:5). The reaction was also investigated after modification of position 2 of the side chain both with one or two fluoro substituents (e.g. to yield product 2).
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