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Dr. Hui Xu, Dr. Wei Huang, Dr. Qing-Li He, Zhi-Xiong Zhao, Feng Zhang, Prof. Dr. Renxiao Wang, Prof. Dr. Jingwu Kang and Prof. Dr. Gong-Li Tang Self-Resistance to an Antitumor Antibiotic: A DNA Glycosylase Triggers the Base-Excision Repair System in Yatakemycin Biosynthesis Angewandte Chemie International Edition 51

Article first published online: 17 SEP 2012 | DOI: 10.1002/anie.201204109

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Resistance is (not) futile: The yatakemycin biosynthetic gene cluster involves the ytkR2 gene, which encodes a protein with homology to a recently discovered bacterial DNA glycosylase. Genetic validation in vivo, biochemical assays, and in vitro mutagenesis studies revealed that YtkR2 confers resistance for the bacteria by specifically recognizing and cleaving the YTM-modified base (see scheme).

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