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Lindsay McMurray, Dr. Elizabeth M. Beck and Prof. Matthew J. Gaunt Chemical Synthesis of Aspidosperma Alkaloids Inspired by the Reverse of the Biosynthesis of the Rhazinilam Family of Natural Products Angewandte Chemie International Edition 51

Version of Record online: 22 AUG 2012 | DOI: 10.1002/anie.201204151

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Pyrrole reduction: Iterative metal-catalyzed C[BOND]H functionalization reactions facilitated the preparation of a highly substituted pyrrole derivative. This derivative could be transformed into the pyrrole-containing secondary metabolite, rhazinilam, which could in turn be transformed through a reductive transannular cascade process into the structurally complex pyrrolidine-containing alkaloid natural product, aspidospermidine.

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