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Dr. Jayanta Chatterjee, Prof. Monique Beullens, Dr. Rasa Sukackaite, Junbin Qian, Dr. Bart Lesage, Dr. Darren J. Hart, Prof. Mathieu Bollen and Dr. Maja Köhn Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells Angewandte Chemie International Edition 51

Version of Record online: 7 SEP 2012 | DOI: 10.1002/anie.201204308

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The first cell-penetrating peptide that activates protein phosphatase-1 (PP1) by disrupting a subset of PP1 complexes in living cells has been developed. Activated PP1 rapidly dephosphorylates its substrates, counteracting kinase activity inside cells. Activation of PP1 can thus be a novel approach to study PP1 function and to counteract Ser/Thr kinase activity under pathologically increased kinase signaling.

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