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Kang Chen, Hu Li, Zhi-Quan Lei, Yang Li, Wen-He Ye, Li-Sheng Zhang, Prof. Jian Sun and Prof. Dr. Zhang-Jie Shi Reductive Cleavage of the C sp 2[BOND]C sp 3 Bond of Secondary Benzyl Alcohols: Rhodium Catalysis Directed by N-Containing Groups Angewandte Chemie International Edition 51

Version of Record online: 31 AUG 2012 | DOI: 10.1002/anie.201204338

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Cutting loose: 1,1-Biarylmethanol substrates undergo reductive cleavage of the C[BOND]C bond in the presence of a cationic RhIII catalyst and H2 (see scheme; DG=directing group). Various functional groups are tolerated in the reaction system. Preliminary studies indicate that a five-membered rhodacycle intermediate, which then converts into a RhIII hydride species for the reduction, is involved in the catalytic cycle.

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