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Svenja Staudt, Edyta Burda, Carolin Giese, Christina A. Müller, Dr. Jan Marienhagen, Prof. Dr. Ulrich Schwaneberg, Prof. Dr. Werner Hummel, Prof. Dr. Karlheinz Drauz and Prof. Dr. Harald Gröger Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water Angewandte Chemie International Edition 52

Version of Record online: 21 JAN 2013 | DOI: 10.1002/anie.201204464

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It doesn′t take much to oxidize cycloalkanes directly to the corresponding cyclic ketones: molecular oxygen as the oxidant, water as the solvent, the cofactor NADP+ (and a little 2-propanol to reduce it), as well as two catalytic enzymes—a hydroxylating P450 monooxygenase and an alcohol dehydrogenase (see scheme).

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