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Dr. Danling Wang, Dr. Jianing Wang, Dr. Ghislain M. C. Bonamy, Dr. Shelly Meeusen, Richard G. Brusch, Carolina Turk, Dr. Pengyu Yang and Prof. Dr. Peter G. Schultz A Small Molecule Promotes Mitochondrial Fusion in Mammalian Cells Angewandte Chemie International Edition 51

Version of Record online: 21 AUG 2012 | DOI: 10.1002/anie.201204589

Thumbnail image of graphical abstract

Mitochondrial dynamics: An image-based screen identified a small molecule, M1, that specifically promotes the fusion of fragmented mitochondria and protects cells from mitochondrial-fragmentation-associated cell death. Mechanistic studies revealed that M1 shifts the mitochondrial dynamic balance towards fusion (see picture).

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