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Nikolaus Krall, Dr. Jörg Scheuermann and Prof. Dario Neri Small Targeted Cytotoxics: Current State and Promises from DNA-Encoded Chemical Libraries Angewandte Chemie International Edition 52

Version of Record online: 7 JAN 2013 | DOI: 10.1002/anie.201204631

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On target: Antibodies have emerged as promising vehicles for the targeted delivery of potent cytotoxic agents to sites of disease. This Review surveys how the use of smaller organic molecules can yield targeted constructs with improved properties and how DNA-encoded library technologies will facilitate the discovery of the necessary ligands (see scheme).

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