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Alessandro Agostini, Dr. Laura Mondragón, Dr. Andrea Bernardos, Prof. Ramón Martínez-Máñez, Dr. M. Dolores Marcos, Dr. Félix Sancenón, Dr. Juan Soto, Prof. Ana Costero, Dr. Cristina Manguan-García, Prof. Rosario Perona, Dr. Marta Moreno-Torres, Dr. Rafael Aparicio-Sanchis and Prof. José Ramón Murguía Targeted Cargo Delivery in Senescent Cells Using Capped Mesoporous Silica Nanoparticles Angewandte Chemie International Edition 51

Article first published online: 20 SEP 2012 | DOI: 10.1002/anie.201204663

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Learning to let go with age: Intracellular controlled release of molecules within senescent cells was achieved using mesoporous silica nanoparticles (MSNs) capped with a galacto-oligosaccharide (GOS) to contain the cargo molecules (magenta spheres; see scheme). The GOS is a substrate of the senescent biomarker, senescence-associated β-galactosidase (SA-β-gal), and releases the cargo upon entry into SA-β-gal expressing cells.

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