Malte Gersch, Felix Gut, Dr. Vadim S. Korotkov, Johannes Lehmann, Dr. Thomas Böttcher, Dr. Marion Rusch, Dr. Christian Hedberg, Prof. Dr. Herbert Waldmann, Prof. Dr. Gerhard Klebe and Prof. Dr. Stephan A. Sieber The Mechanism of Caseinolytic Protease (ClpP) Inhibition Angewandte Chemie International Edition 52
Catch me if you can: The ClpP protease mediates protein homeostasis and can be efficiently inhibited by β-lactones. A combination of molecular docking, mutagenesis, activity-based protein profiling, and kinetics studies now reveals the mechanism of ClpP inhibition. A hydrophobic pocket next to the active site allows binding of long aliphatic and aromatic residues. The preferred stereoisomer binds into the oxyanion hole.
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