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Dr. Miriam Colombo, Dr. Serena Mazzucchelli, Veronica Collico, Svetlana Avvakumova, Laura Pandolfi, Prof. Fabio Corsi, Prof. Francesca Porta and Dr. Davide Prosperi Protein-Assisted One-Pot Synthesis and Biofunctionalization of Spherical Gold Nanoparticles for Selective Targeting of Cancer Cells Angewandte Chemie International Edition 51

Version of Record online: 25 JUL 2012 | DOI: 10.1002/anie.201204699

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All bound up: A small variant of protein A (red; see picture) was used as a biotemplate for the synthesis and biofunctionalization of gold nanoparticles (AuNPs). These functionalized AuNPs were able to bind to antibodies (green blocks, trastuzumab; TZ) with a defined orientation, thus showing promise as bio-nanoparticle systems suitable for selective cell labeling by membrane-receptor-specific recognition.

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