Dipl.-Chem. Ulrike Wenge, Prof. Jesper Wengel and Prof. Hans-Achim Wagenknecht Photoinduced Reductive Electron Transfer in LNA:DNA Hybrids: A Compromise between Conformation and Base Stacking Angewandte Chemie International Edition 51
Lock it, but not too much: LNA units (locked or bridging nucleic acids) in LNA:DNA hybrids lead to a negative effect on electron transfer (ET), but they also force the nucleic acid structure in the A-type double helix, which allows a better base stacking than the normal B-type and thus positively influences the ET. This result is significant for the design of nucleic acids of molecular electronics.
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