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Dr. Kui Cheng, Dr. Xiaohui Wang, Shuting Zhang and Prof. Dr. Hang Yin Discovery of Small-Molecule Inhibitors of the TLR1/TLR2 Complex Angewandte Chemie International Edition 51

Version of Record online: 11 SEP 2012 | DOI: 10.1002/anie.201204910

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An important regulator of innate immunity, the protein complex of Toll-like receptors 1 and 2 (TLR1/TLR2) provides an attractive target for the treatment of various immune disorders. The novel compound CU-CPT22 can compete with the binding of the specific lipoprotein ligand to TLR1/TLR2 (see picture) with high inhibitory activity and specificity. Repression of downstream signaling from TNF-α and IL-1β was also observed.

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