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Xiaoming Wang, Fanye Meng, Yan Wang, Dr. Zhaobin Han, Prof. Dr. Yong-Jun Chen, Prof. Dr. Li Liu, Dr. Zheng Wang and Prof. Dr. Kuiling Ding Aromatic Spiroketal Bisphosphine Ligands: Palladium-Catalyzed Asymmetric Allylic Amination of Racemic Morita–Baylis–Hillman Adducts Angewandte Chemie International Edition 51

Article first published online: 15 AUG 2012 | DOI: 10.1002/anie.201204925

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Showing a backbone: The spiroketal backbone of the bis(phosphine) ligand 1 led to good regio- and enantioselectivity in the palladium-catalyzed asymmetric allylic amination of racemic Morita–Baylis–Hillman adducts with aromatic amines. The methodology provides a facile and efficient synthesis of precursors for optically active β-lactam derivatives, including the cholesterol drug Ezetimibe.

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