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Tiago Silva, José Teixeira, Prof. Fernando Remião and Prof. Fernanda Borges Alzheimer’s Disease, Cholesterol, and Statins: The Junctions of Important Metabolic Pathways Angewandte Chemie International Edition 52

Version of Record online: 20 DEC 2012 | DOI: 10.1002/anie.201204964

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Cholesterol (left-hand structure) is an essential component of lipid rafts, in which the biosynthesis of neurotoxic β-amyloid occurs. By blocking the synthesis of cholesterol, statins (right-hand structure: lovastatin) are able to decrease the amyloid load in the central nervous system and lower the risk of dementia and Alzheimer's disease. This behavior is strongly supported by the pleiotropic effects of statins on isoprenylation and neuroinflammation.

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