Imants Kreituss, Yuta Murakami, Dr. Michael Binanzer and Prof. Jeffrey W. Bode Kinetic Resolution of Nitrogen Heterocycles with a Reusable Polymer-Supported Reagent Angewandte Chemie International Edition 51
Shake it up baby! Simply shaking a polymer-supported reagent and the racemic amine at room temperature kinetically resolves a broad range of N-heterocycles with good selectivity. The polymer-supported reagents are robust, easy to regenerate, and can be reused dozens of times. Cleavable acyl groups can be used to give access to both amine enantiomers in a single resolution.
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