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Akihiro Hara, Ryo Morimoto, Yuki Iwasaki, Dr. Tsuyoshi Saitoh, Dr. Yuichi Ishikawa and Prof. Dr. Shigeru Nishiyama Total Syntheses of Amphidinolides B, G, and H Angewandte Chemie International Edition 51

Version of Record online: 24 AUG 2012 | DOI: 10.1002/anie.201204992

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Not one, not two, but three: Total syntheses of amphidinolides B, G, and H, which exhibit strong, nanogram-scale cytotoxicity against various tumor cell lines, have been executed. The synthetic strategy relied on implementation of a diene construction protocol and a diastereoselective aldol process. The 26- and 27-membered macrocyclic lactone rings were efficiently constructed by using ring-closing metathesis (RCM).

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