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Dr. Seok Joon Kwon, Prof. Kyung Bok Lee, Kemal Solakyildirim, Sayaka Masuko, Mellisa Ly, Dr. Fuming Zhang, Dr. Lingyun Li, Prof. Jonathan S. Dordick and Prof. Robert J. Linhardt Signal Amplification by Glyco-qPCR for Ultrasensitive Detection of Carbohydrates: Applications in Glycobiology Angewandte Chemie International Edition 51

Version of Record online: 16 OCT 2012 | DOI: 10.1002/anie.201205112

Thumbnail image of graphical abstract

Tiny amounts of carbohydrates (ca. 1 zmol) can be detected quantitatively by a real-time method based on the conjugation of carbohydrates with DNA markers (see picture). The proposed method (glyco-qPCR) provides uniform, ultrasensitive detection of carbohydrates, which can be applied to glycobiology, as well as carbohydrate-based drug discovery.

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