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Chen Cheng and Prof. Dr. Maurice Brookhart Efficient Reduction of Esters to Aldehydes through Iridium-Catalyzed Hydrosilylation Angewandte Chemie International Edition 51

Article first published online: 21 AUG 2012 | DOI: 10.1002/anie.201205154

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Trumping DIBALH: A new method for reduction of esters to aldehydes through silyl acetal intermediates involves a single-step hydrosilylation catalyzed by a readily available iridium complex, [{Ir(coe)2Cl}2] (see scheme; coe=cyclooctene). The low catalyst loading, mild reaction conditions, high conversions, and broad substrate scope make this method a superior alternative to ester reduction using DIBALH.

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