E-mail a Wiley Online Library Link

Kiril Tishinov, Kristina Schmidt, Priv.-Doz. Daniel Häussinger and Prof. Dr. Dennis G. Gillingham Structure-Selective Catalytic Alkylation of DNA and RNA Angewandte Chemie International Edition 51

Version of Record online: 22 OCT 2012 | DOI: 10.1002/anie.201205201

Thumbnail image of graphical abstract

Nuc 'em: A variety of nucleic acids can be catalytically alkylated with rhodium-carbenoids generated from diazo compounds in aqueous buffer through an N[BOND]H insertion process (see scheme; MES=2-(N-morpholino)ethanesulfonic acid). The method specifically targets unpaired bases such as those present in single strands, turn regions, and overhangs while leaving double-stranded sequences untouched.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field