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Kiril Tishinov, Kristina Schmidt, Priv.-Doz. Daniel Häussinger and Prof. Dr. Dennis G. Gillingham Structure-Selective Catalytic Alkylation of DNA and RNA Angewandte Chemie International Edition 51

Version of Record online: 22 OCT 2012 | DOI: 10.1002/anie.201205201

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Nuc 'em: A variety of nucleic acids can be catalytically alkylated with rhodium-carbenoids generated from diazo compounds in aqueous buffer through an N[BOND]H insertion process (see scheme; MES=2-(N-morpholino)ethanesulfonic acid). The method specifically targets unpaired bases such as those present in single strands, turn regions, and overhangs while leaving double-stranded sequences untouched.

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