E-mail

E-mail a Wiley Online Library Link

Brett A. Hopkins and Prof. Dr. John P. Wolfe Synthesis of Enantiomerically Enriched Imidazolidin-2-Ones through Asymmetric Palladium-Catalyzed Alkene Carboamination Reactions Angewandte Chemie International Edition 51

Article first published online: 31 AUG 2012 | DOI: 10.1002/anie.201205233

Thumbnail image of graphical abstract

Positive water effect: A catalyst composed of [Pd2(dba)3] (dba=dibenzylideneacetone) and (S)-Siphos-PE is effective for the enantioselective coupling of N-allyl ureas with aryl bromides to afford 4-substituted imidazolidin-2-ones. Added water leads to significantly improved enantioselectivities with electron-poor aryl halide substrates. It is suggested that the C[BOND]C bond-forming reductive elimination is the enantiodetermining step in these reactions.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.

SEARCH