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Dr. Masayuki Endo, Yangyang Yang, Dr. Yuki Suzuki, Kumi Hidaka and Prof. Hiroshi Sugiyama Single-Molecule Visualization of the Hybridization and Dissociation of Photoresponsive Oligonucleotides and Their Reversible Switching Behavior in a DNA Nanostructure Angewandte Chemie International Edition 51

Article first published online: 10 SEP 2012 | DOI: 10.1002/anie.201205247

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A framed photo of DNA: A pair of photoresponsive oligonucleotides containing azobenzene moieties was introduced into double-stranded DNA within the cavity of a DNA nanostructure (see scheme). The two dsDNAs, in contact at the center, were dissociated using UV irradiation and hybridized with visible light; this was directly observed using high-speed atomic force microscopy.

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