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Dr. Alexander O. Brachmann, M. Sc. Daniela Reimer, Wolfram Lorenzen, Eduardo Augusto Alonso, Yannick Kopp, Prof. Dr. Jörn Piel and Prof. Dr. Helge B. Bode Reciprocal Cross Talk between Fatty Acid and Antibiotic Biosynthesis in a Nematode Symbiont Angewandte Chemie International Edition 51

Version of Record online: 24 OCT 2012 | DOI: 10.1002/anie.201205384

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Don't play the second fiddle! The identification of different arrangements of branched-chain keto acid dehydrogenases usually involved in the biosynthesis of cellular building blocks is demonstrated (see scheme). Direct cross talk between secondary metabolism ketosynthases (KS) and fatty acid biosynthesis is shown and the biosynthesis of odd-numbered iso-fatty acids is found to be connected to the production of pristinamycin IIa.

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