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Dr. Jun Zhou, Dr. Anne Bourdoncle, Dr. Frédéric Rosu, Dr. Valérie Gabelica and Dr. Jean-Louis Mergny Tri-G-Quadruplex: Controlled Assembly of a G-Quadruplex Structure from Three G-Rich Strands Angewandte Chemie International Edition 51

Article first published online: 4 OCT 2012 | DOI: 10.1002/anie.201205390

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In my (DNA) dreams: A tri-G-quadruplex was constructed from three strands (T1–T3) of DNA using duplex formation to guide the G-rich tracts into close proximity with the addition of Li+ ions (see scheme). The defined G-quadruplex structure was formed upon addition of Na+ ions and characterized by gel electrophoresis and spectroscopy.

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