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Peng Wang, Dr. Woncheol Kim, Dr. Lauren B. Pickens, Xue Gao and Prof. Yi Tang Heterologous Expression and Manipulation of Three Tetracycline Biosynthetic Pathways Angewandte Chemie International Edition 51

Version of Record online: 28 SEP 2012 | DOI: 10.1002/anie.201205426

Thumbnail image of graphical abstract

A very accommodating host: Three tetracycline biosynthetic pathways were overexpressed and manipulated in the heterologous host Streptomyces lividans K4-114. Through the inactivation of various genes and characterization of the resulting biosynthetic intermediates, new tetracycline-modifying enzymes were identified (see scheme).

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