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M. Sc. Gabriel Monzón, Dr. Ilaria Tirotta and Prof. Dr. Paul Knochel The ortho and meta Magnesiation of Functionalized Anilines and Amino-Substituted Pyridines and Pyrazines at Room Temperature Angewandte Chemie International Edition 51

Version of Record online: 20 SEP 2012 | DOI: 10.1002/anie.201205465

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A practical ortho,meta, (or even ortho,ortho′) magnesiation of trifluoroacetamides of anilines, aminopyridines, and aminopyrazines at room temperature was performed with TMPMgCl⋅LiCl or TMP2Mg⋅2 LiCl. These magnesiations are compatible with several carbonyl functionalities and allow access to polysubstituted anilides in satisfactory yields.

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