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Dr. Christopher M. Clouthier, Gleb G. Mironov, Dr. Victor Okhonin, Prof. Maxim V. Berezovski and Prof. Jeffrey W. Keillor Real-Time Monitoring of Protein Conformational Dynamics in Solution Using Kinetic Capillary Electrophoresis Angewandte Chemie International Edition 51

Article first published online: 6 NOV 2012 | DOI: 10.1002/anie.201205575

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Conformational analysis: Capillary electrophoresis (CE) allows for the rapid separation of slowly interconverting protein conformers. Kinetic analysis (kopen, kclosed, and Kd) of electropherograms in the presence and absence of effector ligands allows the measurement of kinetic and thermodynamic constants associated with conformational changes and ligand binding.

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