Dr. Bo Yang, Dr. Keisuke Yoshida, Dr. Zhaojun Yin, Hang Dai, Herbert Kavunja, Dr. Mohammad H. El-Dakdouki, Suttipun Sungsuwan, Steven B. Dulaney and Prof. Dr. Xuefei Huang Chemical Synthesis of a Heparan Sulfate Glycopeptide: Syndecan-1 Angewandte Chemie International Edition 51
Finishing first: The highly complex structure of the title compound (see picture) was assembled. The protective groups utilized, as well as the sequences for formation of the glycosyl linkages and protecting group removal are critical to the success of the synthesis. This first preparation of a heparan sulfate glycopeptide lays the foundation for accessing other members of this class of molecules.
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