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Yelena Kravtsova-Ivantsiv, Thomas Sommer and Aaron Ciechanover The Lysine48-Based Polyubiquitin Chain Proteasomal Signal: Not a Single Child Anymore Angewandte Chemie International Edition 52

Article first published online: 4 NOV 2012 | DOI: 10.1002/anie.201205656

Thumbnail image of graphical abstract

Since its discovery more than three decades ago, the proteasomal targeting signal was accepted to be a polyubiquitin chain, in which the ubiquitin moieties are linked to one another through lysine 48 (K48, see picture), and which is anchored to one of the internal lysines of the target substrate. However, recent evidence suggests that the signal for proteasomal targeting is far more diverse and complex.

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