Dr. Michael Whitney, Dr. Elamprakash N. Savariar, Dr. Beth Friedman, Rachel A. Levin, Dr. Jessica L. Crisp, Heather L. Glasgow, Dr. Roy Lefkowitz, Dr. Stephen R. Adams, Paul Steinbach, Nadia Nashi, Dr. Quyen T. Nguyen and Dr. Roger Y. Tsien Ratiometric Activatable Cell-Penetrating Peptides Provide Rapid In Vivo Readout of Thrombin Activation Angewandte Chemie International Edition 52
Article first published online: 18 OCT 2012 | DOI: 10.1002/anie.201205721
In real time: Thrombin activation in vivo can be imaged in real time with ratiometric activatable cell penetrating peptides (RACPPs). RACPPs are designed to combine 1) dual-emission ratioing, 2) far red to infrared wavelengths for in vivo mammalian imaging, and 3) cleavage-dependent spatial localization. The most advanced RACPP uses norleucine (Nle)-TPRSFL as a linker that increases sensitivity to thrombin by about 90-fold (see figure).
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