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David M. Chenoweth, Jordan L. Meier and Prof. Peter B. Dervan Pyrrole-Imidazole Polyamides Distinguish Between Double-Helical DNA and RNA Angewandte Chemie International Edition 52

Article first published online: 14 SEP 2012 | DOI: 10.1002/anie.201205775

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Groove specificity: Pyrrole-imidazole polyamides are well-known for their specific interactions with the minor groove of DNA (see scheme). However, polyamides do not show similar binding to duplex RNA, and a structural rationale for the molecular-level discrimination of nucleic acid duplexes by minor-groove-binding ligands is presented.

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