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Abram Axelrod, Anders M. Eliasen, Matthew R. Chin, Katherine Zlotkowski and Dr. Dionicio Siegel Syntheses of Xanthofulvin and Vinaxanthone, Natural Products Enabling Spinal Cord Regeneration Angewandte Chemie International Edition 52

Article first published online: 19 OCT 2012 | DOI: 10.1002/anie.201205837

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Growth promoting: The first synthesis of the natural product xanthofulvin (SM-216289) has resolved issues regarding its structural assignment and that described for the natural product 411J. The structurally and biologically related natural product vinaxanthone was similarly prepared through a novel dimerization reaction. Treatment of C. elegans with synthetic xanthofulvin and vinaxanthone enhanced axonal branching.

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