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Dr. Kathleen Wood, Dr. François-Xavier Gallat, Dr. Renee Otten, Auke J. van Heel, Mathilde Lethier, Dr. Lambert van Eijck, Martine Moulin, Dr. Michael Haertlein, Dr. Martin Weik and Prof. Dr. Frans A. A. Mulder Protein Surface and Core Dynamics Show Concerted Hydration-Dependent Activation Angewandte Chemie International Edition 52

Version of Record online: 14 NOV 2012 | DOI: 10.1002/anie.201205898

Thumbnail image of graphical abstract

By specifically labeling leucine/valine methyl groups and lysine side chains “inside” and “outside” dynamics of proteins on the nanosecond timescale are compared using neutron scattering (see picture). Surprisingly, both groups display similar dynamics as a function of temperature, and the buried hydrophobic core is sensitive to hydration and undergoes a dynamical transition.

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