Marta Bally, Gustaf E. Rydell, Raphael Zahn, Waqas Nasir, Christian Eggeling, Michael E. Breimer, Lennart Svensson, Fredrik Höök and Göran Larson Norovirus GII.4 Virus-like Particles Recognize Galactosylceramides in Domains of Planar Supported Lipid Bilayers Angewandte Chemie International Edition 51
A sticky situation: Domain-dependent recognition of the glycosphingolipid galactosylceramide by norovirus-like particles (see picture; red/yellow) is shown using supported lipid bilayers (purple) as model membranes. Optimal ligand presentation is found to promote strong binding to GalCer. This presentation can be found at the edges of the glycosphingolipid-enriched domains (green) and binding is repressed in the absence of these domains.
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