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Deepak K. Prusty, Minseok Kwak, Jur Wildeman and Prof. Dr. Andreas Herrmann Modular Assembly of a Pd Catalyst within a DNA Scaffold for the Amplified Colorimetric and Fluorimetric Detection of Nucleic Acids Angewandte Chemie International Edition 51

Article first published online: 17 OCT 2012 | DOI: 10.1002/anie.201206006

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Phosphine ligands were covalently tethered to short oligonucleotide strands such that active palladium complexes formed in the presence of a specific nucleic acid target. This catalytic center on the double-stranded DNA then converted water-soluble iodo-BODIPY dyes, present in excess, into highly emissive deiodinated reporters (see picture). This approach is suitable for the rapid colorimetric or fluorimetric detection of nucleic acid targets with a lower detection limit of just 10 pM.

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