Dr. Chitra R. Edwankar, Dr. Rahul V. Edwankar, Dr. Jeffrey R. Deschamps and Prof. Dr. James M. Cook Nature-Inspired Stereospecific Total Synthesis of P-(+)-Dispegatrine and Four Other Monomeric Sarpagine Indole Alkaloids Angewandte Chemie International Edition 51
All five: The first total synthesis of the C2-symmetric indole alkaloid 1 involved a late-stage thallium(III) acetate-mediated intermolecular oxidative coupling to construct the C9C9′ bond with complete regio- and stereocontrol. The formation of a single atropodiastereomer in this critical step arises from internal asymmetric induction. The first total synthesis of four other monomeric sarpagine indole alkaloids is also described.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf