E-mail a Wiley Online Library Link

Dr. Grégory Danoun, Dr. Anis Tlili, Dr. Florian Monnier and Dr. Marc Taillefer Direct Copper-Catalyzed α-Arylation of Benzyl Phenyl Ketones with Aryl Iodides: Route towards Tamoxifen Angewandte Chemie International Edition 51

Version of Record online: 9 NOV 2012 | DOI: 10.1002/anie.201206024

Thumbnail image of graphical abstract

No activation needed: The first efficient method for direct α-arylation of non-activated or non-protected family of enolizable ketones with simple aryl iodides employs a catalytic copper system. The method shows potential for the easy and step-economical synthesis of tamoxifen, the most commonly administrated drug for the management of breast cancer. R, R′, R′′ = electron-donating or electron-withdrawing groups.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field