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Guosong Hong, Dr. Joshua T. Robinson, Yejun Zhang, Shuo Diao, Alexander L. Antaris, Prof. Qiangbin Wang and Prof. Hongjie Dai In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near-Infrared Region Angewandte Chemie International Edition 51

Version of Record online: 5 SEP 2012 | DOI: 10.1002/anie.201206059

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Hits the dot: Ag2S quantum dots (QDs) with bright near-infrared-II fluorescence emission (around 1200 nm) and six-arm branched PEG surface coating (see scheme) were synthesized for in vivo small-animal imaging. The 6PEG-Ag2S QDs afforded a tumor uptake of approximately 10 % injected dose/gram, owing to a long circulation half-life of approximately 4 h. Clearance of the injected 6PEG-Ag2S QDs occurs mainly through the biliary pathway in mice.

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