Alexander Gutmann and Prof. Dr. Bernd Nidetzky Switching between O- and C-Glycosyltransferase through Exchange of Active-Site Motifs Angewandte Chemie International Edition 51
Mechanistic implications: Distinct active-site motifs in plant aryl glucosyltransferases of the GT-1 family differentiate between C- and O-glycosylation activity on a phloretin acceptor. In the implicated protein design principle the exchange of active-site motifs results in reversible switch between C/O-glycoside specificity. The proposed mechanism of the C-glycosyltransferase involves direct nucleophilic displacement at the anomeric carbon.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf