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Guangchuan Wang, Xiaofeng Li, Lijuan Mo, Zhiyong Song, Wei Chen, Yongqiang Deng, Hui Zhao, Ede Qin, Prof. Dr. Chengfeng Qin and Prof. Dr. Ruikang Tang Eggshell-Inspired Biomineralization Generates Vaccines that Do Not Require Refrigeration Angewandte Chemie International Edition 51

Version of Record online: 24 SEP 2012 | DOI: 10.1002/anie.201206154

Thumbnail image of graphical abstract

We're not gonna bake it: In situ biomineralization creates an egg-like shell on vaccine particles to improve their thermostability. Different from the bare vaccine (squares), the biomineralized vaccine (red circles) can be stored at ambient temperature without refrigeration for up to a week and retain biological activity both in vitro (see graph), as well as in a mouse model.

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