Manh V. Pham, Baihua Ye and Prof. Dr. Nicolai Cramer Access to Sultams by Rhodium(III)-Catalyzed Directed CH Activation Angewandte Chemie International Edition 51
Director's cut: The pharmaceutically relevant sulfonamide group is shown to be a competent directing group for [Cp*Rh(OAc)2]-catalyzed CH functionalizations. Reactions of the cyclometalated intermediate with internal alkynes provide access to a wide range of sultam derivatives. The reaction is high yielding and works best under aerobic conditions with catalytic amounts of CuOAc as an oxidation mediator. Cp*=C5Me5.
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