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Manh V. Pham, Baihua Ye and Prof. Dr. Nicolai Cramer Access to Sultams by Rhodium(III)-Catalyzed Directed C[BOND]H Activation Angewandte Chemie International Edition 51

Version of Record online: 23 SEP 2012 | DOI: 10.1002/anie.201206191

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Director's cut: The pharmaceutically relevant sulfonamide group is shown to be a competent directing group for [Cp*Rh(OAc)2]-catalyzed C[BOND]H functionalizations. Reactions of the cyclometalated intermediate with internal alkynes provide access to a wide range of sultam derivatives. The reaction is high yielding and works best under aerobic conditions with catalytic amounts of CuOAc as an oxidation mediator. Cp*=C5Me5.

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