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Prof. Dr. Kohei Endo, Daisuke Hamada, Sayuri Yakeishi and Prof. Dr. Takanori Shibata Effect of Multinuclear Copper/Aluminum Complexes in Highly Asymmetric Conjugate Addition of Trimethylaluminum to Acyclic Enones Angewandte Chemie International Edition 52

Article first published online: 26 NOV 2012 | DOI: 10.1002/anie.201206297

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Al and friends: Asymmetric conjugate addition of Me3Al to β,β-disubstituted α,β-unsaturated ketones in the presence copper and L1 leads to a highly efficient construction of an all-carbon-substituted chiral quaternary center. This result is the first example of an asymmetric conjugate addition of Me3Al to acyclic enones to give a chiral quaternary carbon center with excellent yield and enantioselectivity under mild reaction conditions.

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