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Florian Rechenmacher, Stefanie Neubauer, Dr. Julien Polleux, Dr. Carlos Mas-Moruno, Dr. Mariarosaria De Simone, Dr. Elisabetta Ada Cavalcanti-Adam, Prof. Joachim P. Spatz, Prof. Reinhard Fässler and Prof. Dr. Horst Kessler Functionalizing αvβ3- or α5β1-Selective Integrin Antagonists for Surface Coating: A Method To Discriminate Integrin Subtypes In Vitro Angewandte Chemie International Edition 52

Article first published online: 12 DEC 2012 | DOI: 10.1002/anie.201206370

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Stuck with the right choice: αvβ3- or α5β1-selective integrin ligands were functionalized for surface coating without losing activity and selectivity. The coating of nanostructured gold surfaces with these compounds stimulated subtype-selective cell adhesion of genetically modified αvβ3- or α5β1-expressing fibroblasts in vitro.

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