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Dr. Amirali Popat, Dr. Benjamin P. Ross, Dr. Jian Liu, Siddharth Jambhrunkar, Prof. Freddy Kleitz and Prof. Shi Zhang Qiao Enzyme-Responsive Controlled Release of Covalently Bound Prodrug from Functional Mesoporous Silica Nanospheres Angewandte Chemie International Edition 51

Article first published online: 5 NOV 2012 | DOI: 10.1002/anie.201206416

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I want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, to generate enzyme-responsive nanocarriers. In the presence of the colon-specific enzyme azo-reductase (orange), 5-ASA and sulfapyridine are efficiently released.

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