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Boyu Zhang, Dr. Zongxuan Jiang, Dr. Xin Zhou, Dr. Shengmei Lu, Dr. Jun Li, Dr. Yan Liu and Prof. Can Li The Synthesis of Chiral Isotetronic Acids with Amphiphilic Imidazole/Pyrrolidine Catalysts Assembled in Oil-in-Water Emulsion Droplets Angewandte Chemie International Edition 51

Version of Record online: 14 NOV 2012 | DOI: 10.1002/anie.201206438

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Drop it! A highly enantioselective catalytic cascade reaction of α-ketoacids and aldehydes is achieved using the title catalyst and water as the solvent. Fluorescence imaging shows that the catalyst is mainly distributed on the surface of emulsion droplets. Optically active isotetronic acids can be obtained with this method and the emulsion droplets are responsible for the high reactivity and enantioselectivity.

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